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01121 Journal of Nara Medical Association >
Vol.60 No.5-6 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/1098
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タイトル: | NON-ALCOHOLIC STEATOHEPATITIS IN NARA MEDICAL UNIVERSITY HOSPITAL BETWEEN 2003 AND 2008 ; RETROSPECTIVE STUDY WITH CLINICOPATHOLOGIC ANALYSIS |
著者: | Kongkarnka, Sarawut Kasai, Takahiko Uemura, Masahito Fukui, Hiroshi Nonomura, Akitaka |
キーワード: | steatohepatitis metabolic syndrome hepatocyte ballooning Mallory bodies perivenular/pericellular fibrosis lipogranuloma |
発行日: | 2009年12月31日 |
出版者: | 奈良医学会 奈良県立医科大学 |
引用: | Journal of Nara Medical Association Vol.60 No.5-6 p.149-158 |
抄録: | Clinical and pathological features of 50 Japanese patients with biopsy proven
non-alcoholic steatohepatitis (NASH) were reviewed. Incidence of NASH patients
increased gradually after 2004, up to 8.06% in the series of liver biopsy specimens.
Twenty-six were male and twenty-four were female with a mean age of 54.66 years
(range 19-80 years old, male: 47.5, female: 62.4 years old). Forty-four percent of patients
were preobese with a body mass index (BMI) between 25 and 30, while 28% of the
patients were non-obese, and only 28% of the cases were morbidly obese, confirming that
Japanese have a greater tendency to develop fatty liver disease than Western people.
Dyslipidemia was found in 30%, diabetes mellitus in 34%, and hypertension in 26% of the
patients. Abnormally elevated liver function tests were found in up to 90% of the
patients and were characteristically mild with 2- to 3- fold elevation from the normal
range in the majority of cases. Histological features of the liver were similar to those
reported in Western literature; steatosis was found in every patient and most of them
were score 1 (34%) and preferential macrovesicular in type. Lobular necroinflammation
was typically mild (combined stage 1 and stage 2,98%). Ballooned hepatocytes were
frequently observed with characteristic small poorly formed Mallory bodies. Pericellular
fibrosis, one of the key histologic features of NASH, was classified in stage 1 in the
majority of the patients (54%), with characteristic acinar zone 3 involvement. As for the
disease progression, portal fibrosis and/or bridging fibrosis could develop leading to
liver cirrhosis (stage 4 NASH) in 10% of the patients. |
URI: | http://hdl.handle.net/10564/1098 |
ISSN: | 13450069 |
出現コレクション: | Vol.60 No.5-6
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