特発性高カルシウム尿症の2例

Abstract

Idiopathic hypercalciuria (IH) is defined as an abnormally high urine calcium excretion rate without original diseases that cause hypercalciuria such as hyperparathyroidism, renal tubular acidosis, vitamin D intoxication, or Cushing syndrome. IH is well-known as one of the causes of urolithiasis in adults. IH has been made much account of as the cause of hematuria in childhood, since Stapleton and his colleague reported hypercalciuria in children with hematuria in 1984. Two girls who had asymptomatic hematuria were diagnosed as IH by the measurement of 24-hour urinary calcium excretion after the screening of measuring the calcium/creatinine concentration ratio in early morning urine. Both cases were judged as absorptive idiopathic hypercalciuria by means of calcium-loading test. They were treated by only mild restriction of salt or calcium and have had no gross hematuria episode after treatment.