臨床化学検査の変動背景因子に関する検討 ： GPT，GOTおよびγ-GTPについて

Abstract

Background clinical laboratory data such as GOT, GPT and γ-GTP were studied in 19,167 outpatients and 62 normal subjects identified with medical screenings. The results are as follows : 1) GPT increased with aging and showed a peak in male patients in their forties and in female patients in their sixties. No difference in GPT between male and female patients in their forties was found with normal subjects in the same range of body weight, 2) GOT decreased in patients till their twenties and increased in male patients thereafter. An abrupt increase in GOT was found in female patients in their fifties. No difference in GOT between male and female patients in their forties was found with normal subjects. 3) γ-GTP showed a similar mode of change with aging to GPT. But no sex-linked difference was found between male and female normal subjects who were non-drinkers. It is suggested that sex-linked difference in GPT, GOT and γ-GTP are mainly associated with body weight, pathological variation and alcohol-intake, respectively.