免疫組織染色を用いたα2-HS glycoproteinの臓器分布

Abstract

Alpha2-HS glycoprotein (α2-HS) is a plasma glycoprotein with a molecular weight of 49 kDa and is synthesized in the liver. Although it is generally accepted that α2-HS is involved in bone metabolism, its physiological functions have not been fully elucidated. Hence, in order to clarify the function of α2-HS, its distribution in the body was investigated by immunohistological staining using tissue samples obtained by autopsy. The results showed that, as previously known, α2-HS existed abundantly in the liver and bones, and was also detected in organs such as heart, pancreas, kidney, small intestine and brain, but not in the lung, spleen or adrenal gland. The results of the present study clarify that α2-HS exists in many organs besides the bones, suggesting that α2-HS is a multi-fUnction protein involved not only in bone metabolism, but also in other physiological reactions.