アルコールの肝における高比重リポ蛋白代謝に及ぼす影響に関する研究

Abstract

The effect of alcohol intake on the serum levels of high-density lipoprotein cholesterol (HDL-ch), apolipoprotein A-Ⅰ (apo. A-Ⅰ), and apolipoprotein A-Ⅱ (apo. A-Ⅱ) was investigated in 19 habitual alcohol drinkers without liver disfunction (Group A), 35 with mild hepatic damage (Group B), and 7 with advanced liver disease (Group C). The serum level of HDL-ch was higher in Group A than in 10 non-drinkers (control group) (P＜0.001). But it was lower in Group B (P＜0.01) and significantly lower in Group C (P＜0.001) than in the controls. The level of apo. A-Ⅰ was also higher in Group A (P＜0.005) than in the controls, although the level of apo. A-Ⅱ was not. To elucidate the effects of alcohol on apo. A-Ⅰ production by hepatocytes, the author investgated the synthesis of apo. A-Ⅰ and albumin by cultured rat liver cells in the presence of ethanol. Ethanol enhanced the production of apo. A-Ⅰ but not that of albumin. These results suggest that the elevation of serum HDL in habitual alcohol drinkers without liver disturbance is mainly attributable to the increase of apo. A-Ⅰ synthesis in the liver.