臓器循環に関する研究 ： 臓器相関の立場からみたβ₁遮断薬Acebutolol投与の影響

Abstract

The hemodynamic properties of acebutolol (Ac), a selective β₁-receptor blocking agent, were examined. To investigate the effects of Ac on systemic and regional hemodynamics in the anesthetized adult mongrel dogs given the drug in a single intravenous dose, the blood flows in several organs were measured at the same time using the electromagnetic flowmeter. The separated renal blood flow (extra-RBF) on the extracorporeal circuit was also measured. The drug was given in doses of 0.01, 0.05 and 0.25 mg/kg. 1) Cardiac output (CO) and heart rate decreased significantly regardless of Ac dosage. 2) Renal blood flow rarely changed. GFR also did not change although the effective renal blood flow (ERBF) decreased. In the extracorporeal circuit, either RBF or ERBF did not change. 3) Carotid blood flow (CBF) decreased with an increase in carotid vascular resistance. 4) Hepatic, superior mesenteric arterial blood flow and portal vein blood flow decreased more markedly, than CO did. The results suggest that CBF and visceral organ blood flows decrease unpredictably after dosing with Ac, and that Ac maintains GFR by intra-renal circulatory redistribution.