ヒト第Ⅹ因子の測定 ：Ⅱ. 新生児期における第Ⅹ因子活性および第Ⅹ因子抗原量について

Abstract

Factor Ⅹ activity by solid-phase immunochromometric assay (F. X : Cɪcm) and factor Ⅹ antigen by ELISA (F. X : Ag) were measured in cord plasmas from newborn infants, and in plasmas of full-term newborn infants during the first month of life without hemorrhagic symptoms. In each group, 50 plasma samples (25 males and 25 females) were collected. In the newborn cord plasma, the levels of F. X : Cɪcm (39.3±8.4 U/dl) and F. X : Ag (40.6±8.1 U/dl) were lower than normal plasma. F. X : Cɪcm and F. X : Ag in the newborn plasma were lowest on the next day of life, i. e., 33.0±9.5 U/dl and 34.6±9.3 U/dl respectively, and increased gradually during the first month, reaching 66.0±13.5 U/dl and 65.7±12.4 U/dl respectively. There was no significant difference in F. X : Cɪcm or F. X : Ag between males and females in each group. These results are discussed in connection with prothrombin, factor Ⅶ and factor Ⅸ values in the newborn period.