新生児期のα₂-アンチプラスミンの動態 ： 成熟児・未熟児の新生児期におけるα₂-アンチプラスミンの推移

Abstract

Levels of α₂-antiplasmin activity (α₂-AP : C) and antigen (α₂-AP : Ag) were measured in 50 normal full-term and 21 premature newborn infants during the first month of life. In full-term infants, the α₂-AP : Ag levels were assayed by electro immuno assay (EIA) and enzyme-linked immunosorbent assay (ELISA). The mean values of α₂-AP : C, α₂-AP : Ag-EIA and α₂-AP : Ag-ELISA were lowest on the first day of life, i. e., 59.5±8.8 u/dl, 61.3±7.1 u/dl and 60.8±9.2 u/dl respectively. The values gradually increased during the first month, reaching 96.2±8.3 u/dl, 99.2±7.1 u/dl and 97.7±8.0 u/dl respectively. Premature infants were divided into three groups based on their birth weight : Group A of 2001-2500 g ; Group B of 1501-2000 g ; Group C of below 1500 g. In Group A, the mean values of α₂-AP : C and α₂-AP : Ag on the first day of life were 59.0±10.0 u/dl and 60.2±9.1 u/dl. The values gradually increased during the first month, reaching 90.6±9.2 u/dl, 91.0±13.8 u/dl respectively. These levels were almost the same as those of full term infants. In Group B, the mean values on the first day of life were 57.2±11.8 u/dl and 56.8 u/dl respectively. These levels moderately increased during the first month, showing 77.8±9.8 u/dl, 75.8±6.8 u/dl. These levels were lower than those of Group A. In Group C, these levels on the first day of life were 56.1±9.3 u/dl and 55.8±7.4 u/dl. These levels slightly increased during the first month, showing 65.5±13.7 u/dl, 66.6±12.8 u/dl respectively. These levels were apparently lower than those of Group A and B. There was no significant difference in α₂-AP : C and α₂-AP : Ag in their samples.