皮膚電気活動、主観的気分変化、精神症状、治療効果に対する向精神薬の影響の研究 : 単回、点滴静注による試み

Abstract

The aim of this study was to examine the possibility that skin conductance level (SCL) and a patient's subjective mood change during intravenous drip injection of psychopharmaca could predict the results of, or response to, phycopharmacotherapy. Sixty-six patients with depression, 42 with neurosis, 25 with schizophrenia and 8 with other psychiatric disorders were investigated on SCL, subjective mood change, and score of Brief Psychiatric Rating Scale (BPRS) during intravenous drip injection of sulpiride or other psychopharmaca. Improved subjective mood changes were significantly correlated to decreased SCL and were also significantly correlated to results of treatment in 1 month and 3 months. For depressive patients a criterion of SCL<4.0μS and improved subjective mood change might be a good predictor of favorable results of, or favorable response to, psychopharmacotherapy.