健康関連QOLをアウトカムとした地域高齢者のコホート研究－藤原京スタディ－ : 予備調査:健常高齢者の認知機能と抑うつ

Abstract

This feasibility investigation for the Fujiwarakyo study, a cohort study focusing on health-related quality of life among the healthy elderly was performed for 5 days in February, 2007. Mental status, one of the investigative components, was evaluated by Mini-Mental State Examination (MMSE), word recall test (one of the subtests of Alzheimer's Disease Assessment Scale-cognitive component-Japanese version: ADAS- Jco9.), and Geriatric Depression Scale, short form (GDS15). Participants consisted of 74 males (mean age: 75.2 y.o.) and 67 females (74.3 y.o.). MMSE scores were distributed from 19 to 30 ; 20 cases (14.2%) were lower than 24 points (dementia range). Mild cognitive impairment (MCI) was found in 9 cases (6.4%), in whom MMSE scores were more than 24 points and less than 1.5 standard deviation (SD) in the word recall test. The mean number of correct answers in the word recall test was 6.0, and they were positively correlated with MMSE scores (R=0.41, P<0.001). GDS15 scores were 2.4 ± 2.0 (mean ± SD) and the healthy elderly with depressive sylnptoms (≧6 points) were 18 cases (12.8%). Scores of MMSE and GDS15 are reported to be affected by gender or education. To exclude these effects, the Fuji'warakyo study to be performed in future is going to consider factors such as gender and education for evaluation dementia, MCI and depressive symptoms.