ラット背部皮弁の生着に及ぼすブクラデシンナトリウム軟膏の影響

Abstract

Dibutyryl cyclic AMP (DBcAMP) ointment has a possibility of successfully increasing flap survival through its pharmacological effects. In this study, the authors investigated the effect of DBcAMP ointment (containing 3%, 5%, 7% DBcAMP) on flap survival, and measured biochemical products (lactate, nor-adrenalin, creatine kenase and lactate dehydrogenase) in the flap tissue using rat dorsal skin flap. The mean length of the surviving flaps in the animals receiving 5% DBcAMP was longer than those in other animal groups. In all portions of the flap, the mean level of lactate in the tissues of the rats reseiving 5% DBcAMP was lower than those in other groups. Thus, use of the ointment containing an appropriate dose of DBcAMP may successfully enhance flap survival. The fact that the length of surviving flap was negatively correlated with the quantity of lactate in the flap tissues suggests that DBcAMP ointment might increase local blood circulation in the flap.