椎骨脳底動脈循環障害時の循環動態と病態生理に関する基礎的研究

Abstract

The rheological dynamic of a simulation model of the vertebrobasilar system (VBS), which was made of silicole, were investigated using the ultrasonic and laser Doppler method. The vestibular function in rats with VBS disorders was measured by an autoradiographic technique. Morphological ischemic changes were assessed by immunohis- tochemical observations. 1. With unilateral vertebral artery (VA) disorders, the rheological dynamics of the basilar artery (BA) developed a turbulent flow with back flow to the ipsilateral VA duct and flow velocity of the ipsilateral VA duct was more slow than the contralateral. 2. With unilateral VA disorders, the flow volume of the anterior inferior cerebellar artery duct on the side of the disorder was a decrease to below about 70% of that on the opposite side. This fact was supported by the velocity distribution of the BA duct. 3. From immunohistochemical studies of Microtuble-associated protein 2 (MAP 2), the loss of MAP 2 reaction was remarkably seen more in dendrite and soma of the vestibular nucleus (VN) than in the cochlear nucleus (CN) by BA trap occlusion for 30 minutes. 4. 0ccluding the unilateral VA for 30 minutes, loss of MAP 2 reaction was remarkable in dendrite and soma of the ipsilateral VN. When hypotension was more added to animals, loss of staining of only dendrites in the ipsilateral VN was more marked. But a clear loss of staining in the bilateral CN was not detected. 5. Following water irrigation (0℃) for 45 minutes, the glucose metabolism in the ip- silateral VN predominated by an autoradiographic technique and that in the contralateral VN of rats with unilateral VA occlusion predominated. with the addition of hypotension, that in the contralateral VN predominated still more. 6. These results suggest that the VBS disorders may tend to cause symptoms such as vertigo and equilibrium dysfunction.