砂ねずみ海馬スライスにおける低酸素負荷に対するアシドーシスの影響

Abstract

We investigated the effect of acidosis on hypoxic neuronal damage using gerbil hippocampal slices. Acidosis could delay the onset of harmful hypoxic depolariza- tion, but the synaptic recovery after reoxygenation was attenuated when acidosis was sustained. Conversely, synaptic recovery was potentiated when acidosis was restored to the physiological milieu during the period of reoxygenation. These results suggest that acidosis exerts a protective effect on hypoxic neuronal damage only when rapid appreciable pH recovery is achieved during reoxygenation.