小児微小変化型ネフローゼ症候群における血液凝固・線溶動態 : 第2報 各種抗血栓因子の動態

Abstract

To elucidate hemostatic condition, plasma levels of antithrombin Ⅲ antigen (AT Ⅲ), heparin cofactor Ⅱ antigen (HC Ⅱ), protein C antigen (PC), protein S antigen (PS : Ag), PS activity (PS : Act) and C 4 b-binding protein (C4bp) were measured both in acute phase and in remission phase of 25 children with freshly developed minimal change nephrotic syndrome (MCNS). The results indicated that AT Ⅲ levels in acute phase were lower than normal levels and in remission phase were not different from normal levels. PC and C4bp levels were higher than normal levels in both phases. PS : Ag levels in acute phase were higher than normal levels and in remission phase not different from normal levels, while PS : Act and HC Ⅱ levels in both phases were not different from normal levels. These findings suggest that anticoagulant factors, especially PC could play an important role to prevent thromboembolic events.