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01121 Journal of Nara Medical Association >
Vol.47 No.6 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/767
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タイトル: | 小児微小変化型ネフローゼ症候群における血液凝固・線溶動態 : 第3報 血中および尿中の可溶性トロンボモジュリンの動態 |
その他のタイトル: | HEMODYNAMICS OF COAGULATION AND FIBRINOLYSIS IN CHILDREN WITH MINIMAL CHANGE NEPHROTIC SYNDROME : Ⅲ. CHANGES IN PLASMA AND URINARY SOLUBLE THROMBOMODULIN |
著者: | 宮里, 馨 中島, 充 中河, いよう 吉岡, 章 高橋, 幸博 上辻, 秀和 |
キーワード: | thrombomodulin minimal change nephrotic syndrome children |
発行日: | 1996年12月31日 |
出版者: | 奈良医学会 |
引用: | 奈良医学雑誌 Vol.47 No.6 p.377-383 |
抄録: | Soluble thrombomodulin (sTM) is a novel marker of damaged endothelial
cell and acts as an anticoagulant. Plasma and urinary sTM in patients with minimal change
nephrotic syndrome (MCNS) in children are demonstrated in this report. In spite of normal
blood creatinine levels, the plasma concentrations of sTM in cases of onset and relapse of
MCNS were elevated as compared with healthy subjects {at onset 37.8±14.9 TU/ml
(Mean±SD), at relapse 21.8±11.1 TU/ml, normal 9.0±2.8 TU/ml}. The urinary concen-
trations of sTM, however, were almost within normal range, and there was no correlation
between plasma and urinary concentrations of sTM. Plasma concentrations of sTM had a
good correlation (r=-0.742) with serum albumin. From these results it is suggested that
high plasma sTM concentration in patients with MCNS at initial episode and in the course
of relapse is likely to act toward anticoagulation. |
URI: | http://hdl.handle.net/10564/767 |
ISSN: | 04695550 13450069 |
出現コレクション: | Vol.47 No.6
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