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01121 Journal of Nara Medical Association >
Vol.46 No.2 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/803
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タイトル: | 早期糖尿病性腎症患者の運動と腎機能に関する研究 |
その他のタイトル: | EFFECTS OF EXERCISE INTENSITY ON RENAL FUNCTION AFTER EXERCISE IN PATIENTS WITH EARLY DIABETIC NEPHROPATHY |
著者: | 石井, 健司 |
キーワード: | early diabetic nephropathy exercise renal function |
発行日: | 1995年4月30日 |
出版者: | 奈良医学会 |
引用: | 奈良医学雑誌 Vol.46 No.2 p.84-94 |
抄録: | The present study was designed to investigate the effect of exercise on renal
function and urinary protein excretion in 20 non-insulin-dependent diabetic patients with
microalbuminuria as compared with 15 healthy volunteers. Patients consisted of 11 males
and 9 females with a mean age of 40 years. The exercise tests were performed on a
treadmill of four different loads ; Ex1,4.7 METs for 10 minutes ; Ex2,4.7 METs for 20
minutes ; Ex3,7.0 METs for 10 minutes ; Ex4,7.0 METs for 20 minutes. Renal plasma flow
(RPF) was measured by PAH clearance. Urinary excretion of albumin, β₂ microglobulin
(β₂ MG) and N-acetyl-β-D-glucosaminidase (NAG) were measured before and after
exercise, respectively. For hormonal function, plasma renin activity (PRA), plasma
aldosterone concentration (PAC), plasma norepinephrine concentration (PNE) and human
atrial natriuretic peptide (h-ANP) were also measured. In both controls and diabetic
patients, RPF significantly decreased with each exercise (Ex1-2). GFR was unchanged
during Ex1-2, but significantly decreased during Ex3-4. Urinary albumin excretion
increased significantly in both groups during Ex2-4, but was unchanged only in the diabetic
patients during Ex1. Urinary excretion of β₂ MG increased significantly in the diabetic
patients with each exercise (Ex1-4), but no such increments were apparent in the controls.
NAG was unchanged in both groups during Ex1-3, but was increased in the diabetic patients
with Ex4. PRA and PAC significantly increased with each exercise (Ex1-4), but did not
increase in the controls during Ex1-2. PNE increased significantly in both groups during
Ex3-4. These findings suggest that exercise below the level of 4.7 METs is an allowable
degree of daily activities in the management of patients with early-stage diabetic
nephropathy. |
URI: | http://hdl.handle.net/10564/803 |
ISSN: | 04695550 13450069 |
出現コレクション: | Vol.46 No.2
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