AUDITORY P300 EVENT-RELATED POTENTIALS AND MINI MENTAL STATE EXAMINATION PERFORMANCE IN DEMENTIA ; EFFECTS OF IDEBENONE AND VINPOCETINE

Abstract

One group of twenty-one demented patients were administered Idebenone 90 mg/day for eight weeks, the other group of thirty-two demented patients were adminis- tered Idebenone 90 mg/day plus Vinpocetine 15 mg/day for eight weeks. Mini Mental State Examination (MMSE) was carried out and auditory event-related potentials (ERPs) were recorded pre-treatment, after four weeks treatment and after eight weeks treatmet. MMSE performance was significantly improved with treatment in both groups. Central P300 latency was shortened in the group which was treated with Idebenone and Vinpocetine, but not in the group which was treated with Idebenone alone. Based on the obtained results, we were convinced that administration of Idebenone and Vinpocetine was very useful in the treatment of vascular dementia.