N-nitr osobis(2-oxopr opyl)amineによるハムスター膵管癌発生に対するウシおよびサメ軟骨水抽出物の影響

Abstract

Effects of shark cartilage water-extract (SCE) and bovine cartilage water-extract (BCE) on pancreatic duct carcinogenesis were investigated using a rapid production model for pancreatic duct carcinoma in hamsters, and the following results were obtained. 1. SCE inhibited activities of MMP-2 and MMP-9 but BCE did not in vitro. 2. BCE did not have beneficial effects on chemoprevention of pancreatic carcinomas. 3. No toxic signs, including growth retardation or loss of pancreatic and liver weights, were observed in hamsters treated with BOP followed by SCE. 4. The diet containing O.4％ SCE reduced significantly the numbers of adenocarcinomas and ductallesions． 5. SCE did not affect the BrdU labeling indices of pancreatic ductal lesions. 6. SCE did not affect expression levels of proenzyme form of MMP-2 and MMP-9 and enzyme form of MMP-2 in adenocarcinomas. These results indicate that SCE possesses inhibitory effects on development of pancreatic carcinomas and that SCE may be a candidate of chemopreventive agent for pancreatic carcinomas.